Diluted Insulin in Young Children: Bigger Volumes for Smaller Patients
Status:
Recruiting
Trial end date:
2022-06-30
Target enrollment:
Participant gender:
Summary
The aim of this study is to compare the pharmacokinetic (PK) profile of diluted insulin
aspart (U25) with undiluted insulin aspart (U100) in school-aged children and adolescents
with type 1 diabetes (T1D) utilizing the euglycemic clamp technique and a standardized meal
in a controlled research environment.
The investigators hypothesize that dilution of insulin aspart (U25) will alter the PK
properties as compared to undiluted aspart.