Overview

Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers

Status:
Completed
Trial end date:
2017-03-01
Target enrollment:
0
Participant gender:
All
Summary
Digital ulcers are one of the most prevalent complications of scleroderma (systemic sclerosis). There can be found few surveys on effect of topical agents on healing process of the ulcers. Thus, the aim of this study is to assess and compare the effects of topical diltiazem on SSc digital ulcers versus topical nitroglycerin.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Mohammad Ali Nazarinia
Collaborator:
Shiraz University of Medical Sciences
Treatments:
Diltiazem
Nitroglycerin
Petrolatum
Criteria
Inclusion Criteria:

- Having the criteria of LeRoy.

- Having ages between 20-70 years old

- Having at least one active digital ulcer

Exclusion Criteria:

- Having co-morbid diseases such as diabetes, thyroid and cardiovascular diseases

- Being smoker, opium addict or alcohol abuser

- Ones received inhaled or oral prostanoid in last 3 months, phosphodiesterase
inhibitors except for intermittent treatment of erectile dysfunction in last 1 month
and the ones received antibiotics 2 weeks prior to the study

- The ones with moderate to severe hepatic impairment or increase in aminotransferase
levels more than 3