Digoxin Versus Ivabradine in Heart Failure With Reduced Ejection Fraction

• Status: Unknown status
• Trial end date: 2014-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Study hypothesis: Comparing the effect of digoxin and ivabradine in chronic heart failure patients with a left ventricular ejection of 35% or lower and sinus rhythm with heart rate 70 beats per minute or higher, and who are taking maximal dose of a beta blocker if tolerated.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kocaeli University
• Treatments: Digoxin

Criteria

1. Inclusion Criteria:

• Left ventricular ejection fraction of 35% or lower (Ischaemic or non-ischaemic etiology)

• Sinus rhythm with heart rate of 70 beats per minute or higher

• Symptomatic heart failure with functional capacity of New York Heart Association class II, III, IV

2. Exclusion Criteria:

• Chronic renal failure with glomerular filtration rate <30 ml/min

• Atrial fibrillation

• Pace maker rhythm

• Advanced stage chronic obstructive lung disease

• Comorbidity with expected survival below 1 year