Diffusion Length of Local Anesthetics in the Subparaneural Space and Duration of Analgesia
Status:
Not yet recruiting
Trial end date:
2025-07-29
Target enrollment:
Participant gender:
Summary
Ultrasound-guided popliteal sciatic nerve block is a widely practiced technique to provide
anesthesia or analgesia for below-knee surgeries. One study named the space between
paraneural sheath and epimysium of sciatic nerve as the subparaneural space. It has been
reported that injection into the subparaneural space has several advantages (improved the
quality of the sensory block and resulted in a longer block duration) over conventional
perineural injection. The investigators conducted this prospective randomized study to test
the hypothesis that, during ultrasound-guided single popliteal sciatic nerve block, diffusion
length of local anesthetics in the subparaneural space could predict anesthetic effect and
duration of analgesia. The results of this study will develop a novel indicator to facilitate
personalized medicine for patients receiving sciatic block.