Differential Mechanisms of Dyspnea Relief in Advanced COPD: Opiates vs. Bronchodilators
Status:
Suspended
Trial end date:
2022-08-01
Target enrollment:
Participant gender:
Summary
Activity-related breathlessness (dyspnea) is the dominant symptom and persists despite
optimal medical care in as many as 50% of patients with advanced chronic obstructive
pulmonary disease (COPD). The objective of this project is to determine the underlying
mechanisms of the activity-related breathlessness in patients with advanced COPD. To study
the different pathways involved in causing breathlessness, we will compare the effects of two
treatments, opiates with oxygen versus bronchodilators, which relieve breathlessness in
different ways.