Differential Efficacy of Corticosteroid Solutions for Non-Operative Treatment of Digit Flexor Tenosynovitis
Status:
Recruiting
Trial end date:
2025-06-15
Target enrollment:
Participant gender:
Summary
Trigger finger is a common cause of hand pain and dysfunction. Its due to chronic
inflammation of the flexor tendon that leads to a pulley system mismatch. Historically it has
been managed either conservatively with corticosteroid injections or through a surgical
release of the A1 pulley. Several corticosteroids have been used for injection-
dexamethasone, methylprednisolone, triamcinolone, betamethasone, paramethasone, etc. The
purpose of out study is to determine if a 0.5 cc injection of Triamcinolone 40 mg/mL will be
the most effective steroid injection for the non-surgical treatment. Approximately 200
subjects will be enrolled and randomized to one of three treatment arms: Triamcinolone
40mg/mL, Triamcinolone 10mg/mL and Soluble dexamethasone 4mg/mL. Treatment success will be
defined as lack of conversion to surgical treatment, or no desire to proceed with surgery
during study period (3 months).