Differential Effects of rhGH vs. rhIGF-1 on Cardiovascular Risk Factors

• Status: Terminated
• Trial end date: 2012-10-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to see if giving growth hormone or insulin-like growth factor-1 (IGF-1) to subjects with growth hormone deficiency effects cardiovascular risk factors differently.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Columbia University
• Collaborator: Tercica
• Treatments: Hormones

Criteria

Inclusion Criteria:

• Adult male age 25-65 with documented growth hormone deficiency on stable doses x 3 months (at least) of any hormone replacement therapies and with stable MRIs x 2 years in the setting of a known pituitary mass.

Exclusion Criteria:

• Female gender

• current GH use or GH use within three months of the study

• diabetes

• hypoglycemia

• liver or kidney disease

• use of drugs that could increase GH secretion (i.e. L-dopa)

• alcohol or substance abuse

• use of investigational drugs within four weeks of our study and use of supraphysiologic doses of steroids within the previous six months.