Different Postoperative Analgesics Use After Ureteroscopy

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

In this study, we will see the feasibility of a non-opioid pain killers in management of acute post-operative period as well as on discharge from the hospital compared to opioid medications for postoperative pain following URS and stent placement.

The objective of this study will be to compare the pain control effects of no opioid and opioid pain killers during the post-operative period. This study will be a Randomized Clinical trial. Data will be collected from department of Urology, PKLI, Lahore. All patients included in this study will undergo ureteroscopic laser lithotripsy of ureter stones. One group will receive tramadol (opioid) while other two groups will receive Paracetamol and diclofenac sodium (NSAIDs) respectively. All subjects will receive one of the three pain killers after ureteroscopy procedure for ureter stones in a randomized fashion. Postoperative pain intensity will be measured by the investigator and the nurse in the first hour after the surgery in the recovery room and then in urology ward at 1,6, 12, 24, 48, & 72 hours using the Numeric Pain Intensity Scale (NPIS).A mean pain score of less than 2 for each category of surgical procedures or analgesics group will be defined as satisfactory pain control. The data will be analyzed using SPSS v 24.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pakistan Kidney and Liver Institute and Research Center
• Treatments: Analgesics; Analgesics, Non-Narcotic

Criteria

Inclusion Criteria:

1. Ureteroscopy procedure performed for ureteric stones between age 18 -60 years.

2. Patients with normal Renal and Liver function tests function tests.

3. Patients having no growth on urine culture will be included in this study.

4. Patients with no previous history of ureteroscopy procedure in past.

Exclusion Criteria:

1. Patients having history of allergic reaction to any type of the drugs to be used in the study.

2. If Paracetamol contraindicated in severe hepatic impairment, or severe active hepatic disease.

3. If Diclofenac contraindicated in compromised renal function, increased risk of bleeding due to clotting disorder, an increased risk of bleeding, gastric ulcers, alcoholism.

4. If tramadol is contraindicated as in alcoholism, depression and drug abuse.

5. When a patient has a history of opioid abuse.

6. When a patient refuses to participate in the study.

7. When patient is unable to give consent.

8. Pregnancy.

9. If the patient has used conventional NSAIDs, Acetaminophen or Tramadol during the 6 hours before surgery,