Different Effects of Non-calcium Phosphate Binders on Serum Calcium

• Status: Completed
• Trial end date: 2020-12-30
• Target enrollment: 0
• Participant gender: All

Summary

Sevelamer hydrochloride (SE) can increase intestinal calcium absorption in contrast to lanthanum carbonate (LA). Study compared effect of LA and SE on serum and urine phosphate and calcium, and hormones regulating mineral-bone metabolism.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of Lodz; Medical Universtity of Lodz
• Collaborator: Shire
• Treatments: Calcium, Dietary; Sevelamer

Criteria

Inclusion Criteria:

• adult patient

• with eGFR ≤45 ml/min

Exclusion Criteria:

• hypercalcemia (>ULN),

• serum phosphate >1.2 times normal value

• calcium-phosphate disturbances not associated with CKD, e.g. Paget disease, osteoporosis, any bone fracture within 6 months before study, multiple myeloma or any neoplastic disease, liver or biliary tract disease, primary hyperparathyroidism