Different Doses of Vitamin A Supplementation and Male and Female Morbidity and Mortality
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
We previously compared the effect on mortality of the half dose and the full dose currently
recommended by WHO. Unexpectedly, the low dose was clearly better for girls, but not for
boys. The girls' response might have depended on the last vaccine received before the OPV and
VAS campaign. We believe that these findings call for confirmation. In connection with a new
campaign, we will examine whether half the dose or the full dose has a more beneficial effect
on mortality and morbidity in girls, and furthermore address the potential effect
modification by the last vaccine received before the supplementation.