Different Anesthesia Maintain Protocol Effect the Outcome of the Patients

• Status: Completed
• Trial end date: 2020-08-05
• Target enrollment: 0
• Participant gender: All

Summary

This prospective open-label randomized study, patients were having elective urological surgery scheduled to last longer than 1 h under necessitating general anesthesia.Group-P: (Propofol group): 3 mg kg-1 min-1 propofol was pumped continuously after endotracheal intubation. Group-PAS: (Propofol and after 20 min adding Sevoflurane group): 3 mg kg-1 min-1 propofol were pumped continuously and add 1% end-tidal sevoflurane 20 minutes after endotracheal intubation. Group-PS: (Propofol and Sevoflurane group): 3 mg kg-1 min-1 propofol were continuously pumped after endotracheal intubation, and 1% sevoflurane was inhaled continuously at the same time. Group-S: (Sevoflurane group): 1% sevoflurane continued to maintain anesthesia after endotracheal intubation. Group-PSu: (Propofol and Sufentanil group): 3 mg kg-1 min-1 propofol, 0.01 μ g kg-1 min-1 sufentanil were pumped continuously at maintain phase

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: China International Neuroscience Institution
• Treatments: Propofol; Sevoflurane; Sufentanil

Criteria

Inclusion Criteria:

• the aged 18-65 yr,

• ASA physical status I, II or III patients

• having elective urological surgery

• operation scheduled to last longer than 1 h

• under necessitating general anesthesia

Exclusion Criteria:

• refused to participate in the study;

• were not able to communicate due to alterations in the level of consciousness, - a history of allergy to opioids

• contraindications inhalational anaesthesia

• family history of malignant hyperthermia

• alcohol or drug abuse

• received central nervous system-active drugs;

• body mass index ≥40 kg/m2

• represent conditions liable to alter the pharmacokinetic and pharmacodynamic behaviors of the intravenous and inhalation anesthetics

• previous head injury, neurologic or psychiatric disease

• any disabling central nervous

• cerebrovascular disease

• current use of psychoactive or anti-convulsive medications

• unstable angina

• manifest congestive heart failure

• airway management was expected to be difficult