Overview

Differences in Endothelial Function Amongst Sitagliptin and Liraglutide Users

Status:
Completed
Trial end date:
2014-09-01
Target enrollment:
0
Participant gender:
All
Summary
Differences in endothelial function amongst Sitagliptin and Liraglutide Users. A randomized, open-label, parallel-group and active controlled trial
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Anna Cruceta
Treatments:
Liraglutide
Sitagliptin Phosphate
Criteria
Inclusion Criteria:

1. Informed consent obtained before any trial-related activities. (Trial-related
activities are any procedure that would not have been performed during normal
management of the subject.)

2. Male or female patients between 45 and 65 years old

3. Pre-existing type 2 diabetes with HbA1c between 7.0 and 9.5%

4. Triglycerides >1.68 mmol/L

5. HDL cholesterol <1.29 mmol/L in women and <1.04 mmol/L in men

6. Systolic blood pressure (SBP) <130 mmHg and diastolic blood pressure (DBP) <85 mmHg or
treatment with antihypertensive agents

Exclusion Criteria:

1. Known or suspected hypersensitivity to trial product(s) or related products

2. Previous participation in this trial. Participation is defined as being randomised.

3. Females of childbearing potential who are pregnant, breast-feeding or intend to become
pregnant or are not using adequate contraceptive, or males who are sexually active and
not surgically sterilised, who or whose partner are not using adequate contraception

4. Moderate or severe renal dysfunction (creatinine clearance <60 ml/min)

5. Previous type 2 diabetes treatment apart from metformin or insulin

6. Current smoker or history of smoking within 6 months prior to screening.

7. Evidence of overt cardiovascular disease, (documented coronary heart disease, class
II-IV congestive heart failure, cerebrovascular disease, or peripheral vascular
disease).

8. Caffeine intake within 24 hours of endothelial function measurements.

9. Use of any drug with known clinically significant sympathetic or parasympathetic
effects, as determined by the Investigator.

10. Initiation or change (dose or treatment regimen) in concomitant blood
pressure-lowering medication within 4 weeks prior to screening and throughout the day.

11. The receipt of any investigational medicinal product within 6 months prior to
screening.

12. Presence of cancer or other significant medical condition

13. Inability to follow verbal or written instructions