Dietary Nitrate and Exercise to Augment Exercise Training Benefits in Subjects With DM+PAD
Status:
Completed
Trial end date:
2014-11-01
Target enrollment:
Participant gender:
Summary
The hypothesis of this proposal is that in subjects with Type II diabetes mellitus (T2D) and
peripheral arterial disease (PAD) with intermittent claudication (IC), regular consumption of
a high nitrate supplement which raises plasma nitrite, in conjunction with 12 weeks of
supervised exercise training at the limb ischemic threshold (SET) will produce a greater
clinical benefit (increases in claudication onset time [COT] and peak walking time [PWT]
relative to a group with the same exercise training but supplemented with placebo .This study
is essentially exploratory in nature and designed to provide us with information to
adequately develop power and execute a larger study. We have previously seen benefits from
nitrate supplementation on function in PAD.