Dietary Histone Deacetylase Inhibitors (HDAC)

• Status: Terminated
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This pilot, three-week study will help scientists understand more about how the foods people eat can modify histone deacetylases, enzymes the body produces naturally. Broccoli sprout extract (BSE) and garlic oil are thought to modify these enzymes. The purpose of this study is to see if taking broccoli sprout extract alone, garlic oil alone, or broccoli sprout extract and garlic oil together, can decrease the action of histone deacetylase (HDAC) and turn on genes in white blood cells. There will be 80 people in this study.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Texas A&M University
• Treatments: Allyl sulfide; Histone Deacetylase Inhibitors

Criteria

Inclusion criteria:

• age: 20 and older

• body mass index 19-30 kg/sq m

• willingness to maintain normal exercise and activity patterns

• willingness to avoid cruciferous vegetables and garlic and related foods (onion etc.) 1 week before and 2 weeks during the trial for a total of 3 weeks

Exclusion criteria:

• tobacco use within the past three months

• engaging in aerobic activity more than 6 hours per week

• being vegetarian or having other restrictive dietary requirements

• consuming >3 alcoholic beverages/day or >10 per week

• having history of diabetes or uremia or other known metabolic disease

• participating in another dietary study within the past three months

• for women, being pregnant or breastfeeding

• gastrointestinal diseases that could increase gut permeability, including Crohn's disease, ulcerative colitis, gastritis

• taking dietary supplements other than those given in the study

• abnormal liver function, CBC, or thyroid values

• individuals taking any drug or medication, prescription or over the counter, including Isoniazid, Saquinavir, Warfarin, Cyclosporine, Acetaminophen, Oxazepam, medications used for HIV/ AIDS, blood clotting, birth control pills, fish oil and medications metabolized by CYPs (CYP1A2, CYP2E1 and CYP3A4) during the dosing period of 1 week and 48 h prior to and after dosing. Exceptions may be made by the study MD and the PI if in their opinion a medication will not interfere with the scientific validity of the study. The study MD will evaluate a medication on a case-by-case basis to determine that efficacy and safety are not adversely affected.

• Individuals who are known to have problems with blood clotting or increased bleeding, including hemophiliacs or anyone recently undergoing or recovering from a surgical procedure.

• soy or garlic allergy