Dietary Glycemic Index, Brain Function and Food Intake in Patients With Type 1 Diabetes Mellitus
Status:
Completed
Trial end date:
2018-05-01
Target enrollment:
Participant gender:
Summary
Processed carbohydrates cause rapid changes in blood sugar and have been associated with
overeating and obesity. We have shown that test meals high in processed carbohydrate affect
brain areas involved in addiction, craving and overeating. It is unknown whether the changes
in blood sugar or the associated higher insulin levels mediate this brain activation and its
likely adverse effects.
Answering this question is important for patients with type 1 diabetes who have elevated
risks of obesity and disordered eating: If blood sugar is the causal mechanism, optimal
insulin coverage should be protective. If insulin is the causal mechanism, however, a diet
high in processed carbohydrate could predispose to overeating and weight gain, as this diet
requires higher insulin doses.
To disentangle these factors, we will study brain activation and relevant blood markers in 15
men with diabetes. In 4 sessions, we will examine meals with differential carbohydrate
properties while giving insulin infusions.
Phase:
N/A
Details
Lead Sponsor:
Boston Children's Hospital Boston Children’s Hospital
Collaborators:
Beth Israel Deaconess Medical Center Brigham and Women's Hospital