Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors
Status:
Recruiting
Trial end date:
2026-09-30
Target enrollment:
Participant gender:
Summary
The continuing increase in prevalence of obesity in older adults including many older
Veterans has become a major health concern. The clinical trial will test the central
hypothesis that a multicomponent intervention consisting of lifestyle therapy (diet-induced
weight loss and exercise training) plus metformin will be the most effective strategy for
reversing sarcopenic obesity and frailty in older Veterans with obesity.
Phase:
Phase 3
Details
Lead Sponsor:
Baylor College of Medicine VA Office of Research and Development
Collaborators:
Baylor College of Medicine Michael E. DeBakey VA Medical Center US Department of Veterans Affairs