Diesel Exhaust and Vascular Function

• Status: Unknown status
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Double-blind, sham- and placebo-controlled randomized study of effects of freshly-generated diluted diesel exhaust inhalation on vascular function. To examine role of adrenergic system a trial of alpha-blocker terazosin is also used. Each participant completes four study sessions, separated by at least three weeks: 1) Diesel exhaust inhalation (DE, controlled at 300 micrograms/cubic meter for two hours) and terazosin (2 mg prior to inhalation exposure); 2) DE plus placebo (matched for terazosin); 3) filtered air plus terazosin; and 4) filter air plus placebo. The investigators assess outcomes of blood pressure, forearm brachial artery ultrasound, and plasma measures of endothelial activation. The investigators hypothesize that DE exposure will be associated with increased blood pressure, decreased brachial artery diameter, and increased circulating endothelins, and that these effects will be attenuated by terazosin administration.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Washington
• Collaborators: Environmental Protection Agency (EPA); National Institute of Environmental Health Sciences (NIEHS)
• Treatments: Prazosin; Terazosin

Criteria

Inclusion Criteria:

• healthy without chronic illness

• Body Mass Index 18.5 - 26.0

• tolerates 2 mg terazosin dose without unacceptable symptoms

• able to return for four exposure sessions

Exclusion Criteria:

• any chronic disease

• tobacco user

• asthma

• elevated cholesterol

• obesity

• hypertension

• diabetes

• any chronic cardiovascular or pulmonary disease

• pregnancy or unwillingness to use effective contraception, if female