Adenomyosis is a common disease in women aged 40-50 years. It associates with dysmenorrhea
and menorrhagia. Hysterectomy was considered the main treatment that could definitively cure
this disease. Other treatment options are increasingly offered, including hormonal
suppression with gonadotropin-releasing hormone agonists or danazol and endometrial ablation.
However, deep adenomyosis responds weakly to the above treatment options, which are commonly
not considered for long-term management because of the associated side effects.
Dienogest is a progestin medication which is used in birth control pills and in the treatment
of endometriosis and adenomyosis. Low-dose combined oral contraceptive (COC) pills have been
widely used as the primary treatment for menorrhagia. COCs can also be used to induce
endometrial atrophy and to decrease endometrial prostaglandin production, which can
consequently improve menorrhagia and dysmenorrhea that are associated with adenomyosis