Didroxyprogesterone Promotes Natural Pregnancy in Infertile Patients With Endometriosis
Status:
Not yet recruiting
Trial end date:
2025-12-10
Target enrollment:
Participant gender:
Summary
Endometriosis (EM) is an important cause of infertility in women of childbearing age.
Laparoscopic surgery is the treatment of EM Related infertility is an important method.
However, excluding other infertility factors, the natural pregnancy rate of EM patients one
year after operation is still significantly lower than that of normal couples. At the same
time, the high recurrence rate of EM often requires drugs to inhibit ovulation after
operation, which forms a paradox with the demand for fertility. One year after operation is
the "golden period" of natural pregnancy. Whether to treat the recurrence of EM without
affecting or even promoting fertility is a key problem to be solved in clinic.
Didroxyprogesterone is the closest natural progesterone. It is widely used in luteal support
and treatment of threatened abortion. It does not affect ovulation and is harmless to
embryos. In recent years, clinical studies have found that it is helpful to the natural
pregnancy of patients with EM after operation, and is beneficial to improve pain symptoms and
reduce the recurrence rate. Basic studies have also confirmed the inhibitory effect of
didroxyprogesterone on em. However, the existing studies with small sample size are not
enough to draw a convincing conclusion that didroxyprogesterone promotes the pregnancy rate
after em, and there is a lack of Chinese data. This study intends to use a multicenter,
prospective, open, randomized controlled clinical trial design to explore the value of
didroxyprogesterone in the treatment of EM related infertility patients, so as to provide
direct evidence for improving the postoperative natural pregnancy rate of EM patients.
Phase:
Phase 3
Details
Lead Sponsor:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Collaborators:
First People's Hospital of Foshan Guangdong Provincial People's Hospital Shenzhen People's Hospital