Dichloroacetate Kinetics, Metabolism and Toxicology
Status:
Completed
Trial end date:
2002-10-01
Target enrollment:
Participant gender:
Summary
Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain
industrial solvents, thus making it a chemical of environmental concern. However, DCA is also
used as an investigational drug for treating various diseases of adults and children, at
doses far greater than those to which humans are normally exposed in the environment. Our
research involves how DCA is metabolized by healthy adults and by children with a fatal
genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.
Details
Lead Sponsor:
National Institute of Environmental Health Sciences (NIEHS)