Diazoxide-Mediated Insulin Suppression in Hyperinsulinemic Obese Men
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The purpose of this study is to explore diazoxide efficacy in treatment of obese men and
assessment of maximal insulin suppression in obese men without hyperglycaemia.
Obesity is associated with markedly elevated plasma insulin levels throughout the day. The
concept is that obese subjects predominantly develop lean tissue resistance against the
glucoregulatory actions of insulin, but remain relatively sensitive to the lipogenic and
antilipolytic effects of insulin in adipose tissue. According to this theory, suppression of
hyperinsulinism by diazoxide, a well known inhibitor of glucose stimulated insulin secretion,
might be useful to treat obesity because it will help to reverse the process of lipid
storage.