Dialysate Sodium Individualization in Hemodialysis
Status:
Terminated
Trial end date:
2008-04-01
Target enrollment:
Participant gender:
Summary
Salt and water excess is an essential mechanism of hypertension. This is particularly
relevant to patients with end stage kidney disease (ESKD) on dialysis. We have demonstrated
that individualization of the sodium concentration in the dialysate as to match the patient's
own serum sodium concentration leads to less thirst, interdialytic weight gain, and better BP
control in hypertensive patients. In this study we will evaluate the mechanisms underlying
this response by measuring systemic hemodynamics, body volume spaces, and biochemical marker
of volume status.