Diagnostic Properties of Aldosterone-Renin Ratio in Primary Aldosteronism Among Hypertensives.

• Status: Unknown status
• Trial end date: 2009-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to evaluate the diagnostic value of the Aldosterone-Renin Ratio (ARR)as a screening test for primary aldosteronism among hypertensives. The test characteristics will be studied. Furthermore, the effect of eplerenone, a selective aldosterone-receptor antagonist will be studied.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Erasmus Medical Center
• Collaborators: Dutch Kidney Foundation; Pfizer
• Treatments: Eplerenone

Criteria

Inclusion Criteria:

• age 18-65 years

• blood pressure above 140 mmHg systolic and above 90 mmHg diastolic

• use of at least 2 antihypertensive drugs

Exclusion Criteria:

• known cause of hypertension, including white-coat hypertension

• severe renal failure (kreat > 200 umol/l)

• BMI above 32 kg/m2

• poorly regulated diabetes mellitus (HbA1C > 8.0 %)

• heart failure

• stroke or myocardial infarction within 6 months before inclusion

• angina pectoris

• pregnancy

• neoplastic disease, within 5 years before inclusion

• alcohol abuse