Cyclosporine (CsA) and Tacrolimus (Tac) are immunosuppressive agents comprising the
cornerstone of treatment among organ transplant recipients. Unfortunately diabetes is a known
complication after transplantation, yet the underlying mechanisms of this type of diabetes
are still unresolved. A direct comparison of the diabetogenic effects of CsA and Tac, without
interference of corticosteroid treatment, has not yet been investigated using a
hyperinsulinemic euglycemic glucose clamp technique, which is the best method for estimating
insulin sensitivity.
Randomized, investigator-blinded cross-over studies will be carried out, studying 10 healthy
subjects and 10 hemodialysis patients. Each participant will receive treatment with CsA, Tac
and placebo respectively in a random order. The results will be of relevance to the choice
and monitoring of immunosuppressive regimens in kidney transplant recipients as well as the
development of better treatment modalities for diabetes.