Diabetic Autonomic Neuropathy and Left Ventricular Function
Status:
Completed
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
Purpose: To investigate the effect of Quinapril (Q) or Losartan (L) or their combination on
definite Diabetic Autonomic Neuropathy (DAN) and left ventricular systolic and diastolic
function (LVF) over a period of 4 years.
Patients-methods: Fifty-nine patients with definite DAN [2 or more of the 4 Cardiovascular
Reflex Tests (CRTs) were abnormal] were studied for 4 years. Patients were randomly allocated
in 3 groups receiving A, 20 mg Q, B, 100 mg L and C, 20 mg Q +100 mg L respectively. CRTs
analyzed with Mean Circular Resultant (MCR), Valsalva index, 30:15 ratio and postural
hypotension. LV function was investigated with radionuclide ventriculography (RNV) at rest.
Ejection fraction was used to assess LV systolic function, while peak filling rate, first
third filling fraction, and atrial contribution to ventricular filling were used to
investigate LV diastolic function. CRTs and RNV were performed at baseline and after 4 years.