Dextroamphetamine as Adjunct in Cocaine/Opiate Dependent Patients - 3

• Status: Completed
• Trial end date: 2001-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate dextroamphetamine sulfate (sustained release) as an adjunct in concurrent cocaine and opiate dependent patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Collaborator: University of Texas
• Treatments: Cocaine; Dextroamphetamine

Criteria

Inclusion Criteria- Subject must:

• Exhibit cocaine and opiate dependence through a DSM-IV diagnosis as determined by SCID.

• Be between 18 and 45 years old

• Women must agree to use contraception

• Have an EKG that has been confirmed by a cardiologist

• Give a cocaine positive urine during screening - Present with evidence of opiate withdrawal

Exclusion Criteria- Subject must not:

• Have a serious medical illness including, but not limited to the following: Hypertension Significant heart disease Clinically significant cardiovascular abnormality Angina Hepatic, renal, or gastrointestinal disorders that could result in an altered metabolism or excretion of study agent

• Have any Axis I disorder that is not related to drug use

• Have current dependence on any psychoactive disorder other than nicotine

• Be on probation or parole for reasons other than those related to drug charges (ASI)

• Be pregnant or lactating

• Have been in any outside treatment in 3 months