The proposed study aims to evaluate safety and efficacy of combined dextroamphetamine
(Dexedrine) and transcranial direct current stimulation (tDCS) with melodic intonation
therapy (MIT) for treatment of aphasia after stroke. The target population is patients with
chronic speech deficits due to a left hemisphere non-hemorrhagic stroke. Findings from this
proposed project will help in the design of future larger studies.The safety phase will use
cross-over, placebo controlled and single-blinded design. 10 participants with post stroke
chronic non-fluent aphasia will undergo two experiments. To study the safety and effect of
combined dextroamphetamine, tDCS and MIT therapy the study will use a parallel-groups,
randomized, sham and placebo controlled, and double-blinded design in which 48 participants
with post stroke chronic non-fluent aphasia will be randomly assigned to receive either 1)
dextroamphetamine therapy with active stimulation, 2) placebo medication with active
stimulation, 3) dextroamphetamine therapy with sham stimulation or 4) placebo medication with
sham stimulation for the same duration.
Phase:
Phase 2
Details
Lead Sponsor:
The University of Texas Health Science Center, Houston