Dexrazoxane as a Protective Agent in Anthracycline Treated Breast Cancer
Status:
Terminated
Trial end date:
2012-02-01
Target enrollment:
Participant gender:
Summary
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop
growing or die. Chemoprotective drugs, such as dexrazoxane, may protect normal cells from the
side effects of chemotherapy. Monoclonal antibodies such as trastuzumab can locate tumor
cells and either kill them or deliver tumor-killing substances to them without harming normal
cells. Radiation therapy uses high-energy x-rays to damage tumor cells. CTnT/cTnI/ANP/BNP
were proved to be used as a biomarker of drug related cardiotoxicity. There are excellent
correlations between the total cumulative dose of doxorubicin, the severity of the resulting
cardiomyopathy, and the level of serum troponin-T.