Dexmedetomidine's Cardiac and Cognitive Influence on Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery

• Status: Unknown status
• Trial end date: 2013-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators hypothesized that dexmedetomidine as an anesthetic adjunct can be used in the setting of off-pump coronary bypass procedure and can provide benefits to cardiac function and cognitive performance on the ground of the dexmedetomidine's characteristics.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Huazhong University of Science and Technology
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) scores are between classⅡand Ⅲ

• undergo off-pump coronary artery bypass grafting (OPCAB)

Exclusion Criteria:

• left ventricular ejection fraction <40%

• left ventricular aneurysm

• acute myocardial infarction in latest two weeks

• atrial fibrillation

• associated vascular diseases

• severe systemic diseases involving the renal and hepatic systems

• respiratory disease( forced vital capacity less than 50% of predicted values ) preoperative left bundle branch block .