Dexmedetomidine vs Propofol on the Recordings of Deep Brain Activity Measured Through Implanted Stimulators
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
This clinical trial has been designed to study and compare changes in deep brain activity
(field potentials) in Parkinson's disease (PD) patients while awake, and during sedation with
dexmedetomidine or propofol. The recording is made through a deep brain stimulation (DBS)
electrode implanted for PD management.
The investigators hypothesize that dexmedetomidine produces fewer changes as compared to
propofol, and that those changes are consistent and recognizable when compared to activity in
patients not exposed to any sedation. Typification of those changes would in the future allow
for patients to undergo this surgery comfortably while not compromising the quality of the
recording and of the final clinical outcome. The principal variable analyzed is the signal's
power in each of the frequency bands, absolute and relative. The analysis will include usual
clinical methods such as rapid Fourier transform (FFT) and window fast Fourier transform
(WFFT), wavelet analysis, Gabor, and coherence.
Phase:
Phase 4
Details
Lead Sponsor:
Clinica Universidad de Navarra, Universidad de Navarra