Dexmedetomidine-propofol-remifentanil Anaesthesia and Reactivity to Noxious Stimuli
Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
Participant gender:
Summary
Dexmedetomidine acts at central nervous system (specifically: at locus caeruleus), providing
sedative and analgesic effects. It is widely used in intensive care. Surgery-related
interventions elicit arousal ('nociceptive') reactions. The effects of dexmedetomidine on the
neurophysiological signs of arousal are studied in surgical patients. Brain waves,
electrocardiogram, Entropy Index, Bispectral Index, and fingertip pulse waves are recorded
and analyzed later on. The course of anaesthesia and surgery are recorded.