Dexmedetomidine-ketamine Combination Versus Fentanyl-midazolam During Bronchoscopy
Status:
Completed
Trial end date:
2020-08-31
Target enrollment:
Participant gender:
Summary
Sedation during flexible bronchoscopy (FB) should maintain an adequate respiratory drive,
ensure maximum comfort for the patient, and warrant that the objectives of the procedure are
achieved. Nevertheless, the optimal sedation method for FB has yet to be established. This
study aimed to compare the standard recommended combination of midazolam-fentanyl (MF) with
that of dexmedetomidine-ketamine (DK) for patient sedation during FB. Patients subjected to
FB were randomly assigned to a DK (n=25) and an MF group (n=25). The primary outcome was the
rate of critical desaturation events (arterial oxygen saturation <80% with nasal oxygen
supply 2 L/min). Secondary outcomes included sedation depth, hemodynamic complications,
adverse events, and patient and bronchoscopist satisfaction.