Malignancy related abdominal and pelvic pain can be debilitating and affects survival as well
as quality of life. Pain from cancer and its treatments can result in anxiety, depression,
fear, anger, helplessness, and hopelessness, and those with both pain and depression have an
amplification of disability and poor quality of life Pancreatic and other upper abdominal
organ malignancies can produce intense visceral pain syndromes that are frequently treated
with splanchnic nerve neurolysis (SNN) or celiac plexus neurolysis (CPN). Dexmedetomidine is
a selective alpha two adreno-receptor agonist. It provides dose-dependent sedation,
analgesia, sympatholysis, and anxiolysis without relevant respiratory depression.
Dexmedetomidine is used as adjuvant to LA drugs in peripheral nerve block, brachial plexus
block and intrathecal anesthesia with satisfactory results. The aim of this study is to
evaluate effect of addition of dexmedetomidine as an adjuvant to alcohol and local
anesthetics for chemical neurolysis to control pain in patients with intra-abdominal
malignancy.