Overview

Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia

Status:
Not yet recruiting
Trial end date:
2025-10-01
Target enrollment:
0
Participant gender:
Female
Summary
The aim of this study is to compare two modes of labour epidural analgesia: programmed intermittent epidural boluses (PIEB) versus continuous epidural infusion (CEI), with patient controlled epidural analgesia (PCEA), using dexmedetomidine in addition to low-dose bupivacaine and through measuring the total volume of local anesthetic received through patient controlled epidural analgesia per hour
Phase:
Phase 2/Phase 3
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Assiut University
Treatments:
Bupivacaine
Dexmedetomidine
Criteria
Inclusion Criteria:

- Age 18 - 45 years

- Scheduled for normal vaginal delivery

- ASA physical status ӀI-IӀӀ.

- Singleton non-complicated pregnancy.

- At least 36 weak of gestation.

- Vertex presentation.

Exclusion Criteria:

- Patient refusal to epidural analgesia.

- History of cardiac, liver, or kidney diseases.

- History of allergy to amide local anesthetics or study medications.

- Any neurological problem.

- History of chronic opioid analgesic use.

- Any contraindication of regional anesthesia.

- Evidence of intrauterine growth restriction or fetal compromise.

- Failed or unsatisfactory analgesic block.

- Body mass index ≥40 kg/m2