Dexmedetomidine and the Inflammatory Response in Pediatric Cardiac Surgery
Status:
Unknown status
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
Cardiopulmonary bypass-assisted surgery initiates a systemic inflammatory response induced by
extrinsic (e.g. anesthesia, contact activation within the extracorporeal circuit,
endotoxemia) and intrinsic (e.g. tissue damage, endothelial cell activation,
ischemia-reperfusion injury of myocardium) factors. This may either be mild or lead to a more
severe clinical condition. Inflammation after pediatric open heart surgery is a parameter
affecting also duration of mechanical ventilatory support. Dexmedetomidine use was associated
with a reduced increase in plasma IL-1, IL-6, TNF-a, and INF-g levels