Dexmedetomidine and Propofol for Pediatric MRI Sedation
Status:
Completed
Trial end date:
2018-10-21
Target enrollment:
Participant gender:
Summary
The purpose of this study is to compare the results of combining two anesthetic medications
(dexmedetomidine and propofol) in low doses with a standard dose of a single drug that is
commonly used to provide sedation/anesthesia for MRI studies in young children (propofol).
The drugs used for the MRI scan in this study will be chosen randomly. Half the patients will
receive small doses of propofol and dexmedetomidine. The other half will receive propofol
administered constantly throughout the scan. Other drugs that may be used include sevoflurane
and nitrous oxide at the start of the sedation (for placing an intravenous), lidocaine (to
reduce the pain of propofol injection) and glycopyrrolate (to prevent the heart rate from
decreasing too low. The investigators will record 5 additional blood pressures and heart
rates. If additional medications are required to complete the scan, the investigators will
administer whatever is necessary. At the end of the study, the investigators will have an
observer record the time it takes for participants to spontaneously open eyes , to be able to
drink liquids and/or eat and to behave as before the study. Also, it is very important that
the investigators find out from participants about changes in behavior, or if eating or
sleeping habits were unusual following completion of the study. For that reason, the
investigators will call participants in a day or so following the MRI scan.
The investigators expect to recruit 40 children between the ages of 12 and 72 months for the
study and hope to have the study completed in December 2018.