Dexmedetomidine and Neuroprotection in Children Undergoing General Anesthesia
Status:
Completed
Trial end date:
2019-10-05
Target enrollment:
Participant gender:
Summary
Neuroapoptosis is induced by the administration of anesthetic agents to the young brain.
Recent studies showed that the a2-adrenoceptor agonist, dexmedetomidine plays a trophic role
during development and is neuroprotective in several settings of neuronal injury in animals.
We hypothesized that neuroprotective effect of dexmedetomidine would be associated with
evidence of brain injury detected by elevation of plasma concentration of glial fibrillary
acid protein in children undergoing general anesthesia.