Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)

• Status: Terminated
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized controlled trial to compare propofol to dexmedetomidine for prolonged sedation (> 24 hours) in critically ill patients who require mechanical ventilation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Chicago
• Collaborators: Hospira, Inc.; Hospira, now a wholly owned subsidiary of Pfizer
• Treatments: Dexmedetomidine; Fentanyl; Midazolam; Propofol

Criteria

Inclusion Criteria:

• >18 years old

• mechanically ventilated through endotracheal tube

• anticipated need for ventilation > 48 hours

• requiring sedative/analgesic medication

Exclusion Criteria:

• on mechanical ventilator > 96 hours

• primary neurologic disease

• post cardiac arrest

• do not speak English (assessment only English language validated)

• pregnancy or lactation

• active myocardial ischemia

• second or third degree heart block

• pancreatitis

• elevated serum triglycerides (> 400 mg/dL)