Dexmedetomidine Versus Morphine and Midazolam in Prevention and Treatment of Delirium After Adult Cardiac Surgery
Status:
Completed
Trial end date:
2015-04-01
Target enrollment:
Participant gender:
Summary
This randomized double-blind parallel clinical study was conducted on 60 patients undergoing
elective cardiac surgery under general anesthesia, at least 60 yr old, ASA I and II, 70-100
kg body weight and height 160-180 cm. Patients were randomized to: group A=30 patients
receiving dexmedetomidine infusion (0.4- 0.7 µg /kg/h) or group B= 30 patients receiving
morphine in a dose of 10-50μg/kg/hr as an analgesic with midazolam in a dose of 0.05mg/kg up
to 0.2 mg/kg repeated as needed. Titration of the study medications infusions was conducted
to maintain light sedation (RASS) (-2 to +1). Primary outcome was the prevalence of delirium
measured daily via Confusion Assessment Method for intensive care. If Delirium and agitation
occurred: haloperidol 2.5-5 mg IV was given in repeated boluses. Secondary outcomes included
ventilation time, additional sedation/analgesia, hemodynamics and adverse effects.