Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine for Intermediate Cervical Plexus Block

• Status: Recruiting
• Trial end date: 2023-04-15
• Target enrollment: 0
• Participant gender: All

Summary

Background: Many thyroidectomy patients suffer from postoperative pain that could delay early hospital discharge and place a significant burden on both the patient and the healthcare team. Bilateral intermediate cervical plexus block (ICPB) provides good analgesia for neck surgery, including thyroidectomy. However, the duration of a single-shot nerve block is usually short. Therefore, adjuvants are used in peripheral nerve blocks.

Objectives: To compare the safety and efficacy of dexmedetomidine versus dexamethasone as adjuvants to bupivacaine in ultrasound-guided intermediate cervical plexus block in patients undergoing total thyroidectomy under general anesthesia.

Patients and Methods: This is a randomized, double-blind, phase four, prospective clinical trial; carried out on 60 patients, who were candidates for total thyroidectomy under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received bilateral ICPB with isobaric bupivacaine plus dexmedetomidine, and group B, received bilateral ICPB with isobaric bupivacaine plus dexamethasone.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Damanhour Teaching Hospital
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Dexmedetomidine

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) physical status ≤ II

• Age from 21 to 60 years

• Body Mass Index (BMI) ≤ 35 kg/m2

Exclusion Criteria:

• ASA physical status > II

• Age < 21 years or > 50 years

• BMI > 35 kg/m2

• Bronchial asthma

• Chronic obstructive pulmonary disease

• Restrictive lung diseases

• Sick sinus syndrome

• Sinus bradycardia

• Hypertension

• Chronic hypotension

• Ischemic heart disease

• Coagulopathies

• Hepatic insufficiency

• Renal insufficiency

• Diabetes mellitus

• Peripheral neuropathy

• Thyroid malignancy

• Hyperthyroidism

• Substernal goiter

• Patients on beta-blockers

• Patients using pacemakers

• Alcohol or drug abuse

• Allergy to the study drugs