Dexmedetomidine Verses Propofol for Paediatric MRI Brain
Status:
Completed
Trial end date:
2014-03-01
Target enrollment:
Participant gender:
Summary
MRI though not painful requires deep sedation for children due to the loud noise created.
With deep sedation comes respiratory depression so the interest in Dexmedetomidine. For
standardization MRI brain was chosen and also for the fact that patients usually have history
of convulsions where drugs like ketamine may not be a good option. Patients were recruited
after ethics committee approval. After pre-medication with intranasal midazolam 0.2 mg/kg
body weight, Intravenous access was established and then patients were divided in two groups.
One group received intravenous propofol 2mg/Kg and infusion of 100mcg/per kg body weight per
minute. The other group received intravenous bolus of Dexmedetomidine 1mcg/kg over 10 minutes
and then a infusion of Dexmedetomidine 1mcg/kg/hour.
Primary out come was to study the recovery time of patients sedated with Dexmedetomidine
compared to patients sedated with propofol for paediatric MRI brain. Secondary outcome were
analysed in terms of time for induction,procedural disruptions due to awakening and
haemodynamic stability . Follow up was done on phone for any adverse events.