Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery

• Status: Active, not recruiting
• Trial end date: 2022-12-07
• Target enrollment: 0
• Participant gender: All

Summary

Delirium is common in the elderly after orthopedic surgery and is associated with worse outcomes. The investigators hypothesize that, for elderly patients after orthopedic surgery, dexmedetomidine supplemented intravenous analgesia can reduce the incidence of delirium and improve the long-term outcomes.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University First Hospital
• Collaborator: Beijing Jishuitan Hospital
• Treatments: Analgesics; Dexmedetomidine; Dsuvia; Sufentanil

Criteria

Inclusion Criteria:

• Age ≥ 65 years but < 90 years;

• Scheduled to undergo total knee/hip replacement surgery, or spinal surgery;

• Planned to use patient-controlled intravenous analgesia (PCIA) after surgery.

Exclusion Criteria:

• Refuse to participate in this study;

• Preoperative history of schizophrenia, epilepsy, Parkinsonism, or myasthenia gravis;

• Inability to communicate in the preoperative period because of coma, profound dementia or language barrier;

• Preoperative obstructive sleep apnea (diagnosed sleep apnea syndrome or a STOP-Bang score ≥3 combined with a serum bicarbonate ≥28 mmol/L);

• Sick sinus syndrome, severe sinus bradycardia (< 50 beats per minute), or second-degree or above atrioventricular block without pacemaker;

• Severe hepatic dysfunction (Child-Pugh class C);

• Severe renal dysfunction (requirement of renal replacement therapy before surgery);

• American Society of Anesthesiologists physical status >IV, or estimated survival ≤24 h.