60 patients ASA I-III, undergoing orthopedic surgery will be randomly assigned into one of
three groups, namely group A (n=20), where dexmedetomidine will be used for sedation (initial
bolus dose followed by continuous infusion), group B (n=20) where midazolam will be used for
sedation (initial bolus dose followed by continuous infusion) and group C (n=20), where
remifentanil will be used for sedation (initial bolus dose followed by continuous infusion).
All patients will receive spinal anesthesia. Duration of postoperative analgesia, total dose
of patient controlled IV morphine, sedation scores, nausea and vomiting, time of ambulation,
sleep quality and patient satisfaction will be recorded for the first postoperative day.
Additionally chronic pain on the site of surgery will be recorded in 3 and 6 months
postoperatively.