Overview

Dexmedetomidine,Ketamine and Their Combination to Bupivicaine on Thoracic Epidural Analgesia

Status:
Completed
Trial end date:
2018-04-01
Target enrollment:
0
Participant gender:
Female
Summary
This study investigate the effect of addition dexmedetomidine, ketamine or their combination to bupivacaine in thoracic epidural analgesia on acute postoperative pain after breast cancer surgery.
Phase:
Phase 2/Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Assiut University
Treatments:
Bupivacaine
Dexmedetomidine
Ketamine
Criteria
Inclusion Criteria:

- Patients scheduled for modified radical mastectomy.

- ASA Physical status I, II and III.

Exclusion Criteria:

- Patients' refusal.

- Uncooperative patients & severe psychiatric illness (cannot evaluate their own pain
intensity using visual analogue scale (VAS).

- Patients with history of drug allergy.

- severe renal or liver impairment, unstable ischemic heart disease

- Any contraindications to epidural analgesia (coagulopathy, recent -less than 1
week-treatment with thrombolytic or potent antiplatelet drugs as clopidogrel, and
local infection).