Dexmedetomidine Combined With Lidocaine Infusion Affect PONV
Status:
Recruiting
Trial end date:
2021-01-12
Target enrollment:
Participant gender:
Summary
BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine
decreased the incidence of postoperative nausea and vomiting (PONV). The investigators
investigated whether IV lidocaine plus dexmedetomidine infusion could better reduce the
incidence of PONV after laparoscopic hysterectomy.
METHODS: Two hundred and forty women with elective laparoscopic hysterectomy were randomly
divided into four groups: the control group (group C, n=60) received an equal volume of
saline, the lidocaine group (group L, n=60) received IV lidocaine (bolus infusion of 1.5
mg/kg over 10 min, 1.5 mg/kg/h continuous infusion), the dexmedetomidine group (group D,
n=60) received dexmedetomidine administration (bolus infusion of 0.5 µg/kg over 10 min, 0.4
µg/kg/h continuous infusion), the lidocaine plus dexmedetomidine group (group LD, n=40)
received combination of lidocaine (bolus infusion of 1.5 mg/kg over 10 min, 1.5 mg/kg/h
continuous infusion) and dexmedetomidine administration (bolus infusion of 0.5 µg/kg over 10
min, 0.4 µg/kg/h continuous infusion). Primary outcome was the incidence of the first 48 h
nausea, vomiting and PONV after surgery. The secondary outcomes included perioperative
propofol and remifentanil consumption, postoperative fentanyl requirement, Ramsay sedation
score, and bradycardia during post-anaesthesia care unit (PACU) stay.