Dexmedetomidine Combined With Hydromorphone in Tonsillectomy and Adenoidectomy
Status:
Completed
Trial end date:
2019-04-01
Target enrollment:
Participant gender:
Summary
Tonsillectomy and adenoidectomy is one of the most common pediatric surgeries, and agitation
and severe postoperative pain have been considered a very common complications.
Dexmedetomidine mainly inhibits the release of norepinephrine by acting on the α-adrenergic
receptor of the brainstem nucleus, which can produce good sedative effects. Hydromorphone has
a longer duration of action than fentanyl, and it also has a certain sedative effect. The
combination of the two is more conducive to the management of postanesthetic agitation and
pain. This study was to compare the effect of different doses of dexmedetomidine combined
with hydromorphone in the sedation and analgesia after pediatric tonsillectomy and
adenoidectomy.