Dexmedetomedine and Ketamine in Erector Spinae Block for Postoperative Analgesia Following Mastectomy.
Status:
Recruiting
Trial end date:
2023-08-30
Target enrollment:
Participant gender:
Summary
Persistent pain after breast cancer surgery is frequently observed in more than 60% of
patients.The suboptimal management of perioperative pain can lead to the occurrence of
persistent breast cancer pain syndrome and phantom breast pain. Dexmedetomidine, a novel
α2-agonist with an eight-fold affinity for α2-adrenergic receptors (sedate and analgesic
effects) as clonidine, while exerts much less α1-effects., has been found to significantly
increase the duration of peripheral nerve blocks, with minimal systemic side effects.
Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptors. It is
used for sedation, premedication, induction, and maintenance of general anesthesia. Central,
regional, and local anesthetic and analgesic properties have been reported for ketamine. Both
can be used through Erector spinae plane block for postoperative pain control.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
National Cancer Institute, Egypt
Treatments:
Anesthetics Anesthetics, Local Bupivacaine Ketamine