Dexamethasone vs Ondansetron After Cesarean Delivery

• Status: Not yet recruiting
• Trial end date: 2026-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

The goal of this clinical trial is to compare medications in women having a cesarean delivery. The main question it aims to answer are:

• Which medication is better to use as a first-line prevention agent for nausea and vomiting Participants will rate their nausea, pain and other symptoms after surgery Researchers will compare two drugs, ondansetron and dexamethasone to see if the side effects of pain medications are improved after cesarean.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beth Israel Deaconess Medical Center
• Treatments: Dexamethasone; Ondansetron

Criteria

Inclusion Criteria:

• Healthy women (ASA 2)

• Between 18 and 45 years old

• Singleton term pregnancies

• Scheduled or non-labor cesarean delivery

• Neuraxial (spinal or combined-spinal epidural) anesthesia

Exclusion Criteria:

• Refusal to participate

• Known allergy or contraindication to any medication used in the study

• Significant medical or obstetrical disease (ASA ≥ 3)

• Antiemetic use within 24 hours preceding cesarean delivery

• Insulin dependent diabetes

• Hyperemesis gravidarum or chronic antiemetic use

• History of daily or near-daily steroid use during pregnancy

• Opioid use disorder or other chronic pain syndrome

• Opioid use during pregnancy

• Use of antipruritus medication, pruritic urticarial papules of pregnancy, or cholestasis of pregnancy