To evaluate the effect of corticosteroids on reducing elevated intracranial pressure in
cryptococcal meningitis. To evaluate the safety of corticosteroids in patients with
cryptococcal meningitis and intracranial hypertension.
In AIDS patients with cryptococcal meningitis, a correlation has been found between early
death and elevated intracranial pressure. Since dexamethasone has been found to reduce
intracranial pressure resulting from other forms of meningitis, it may be of benefit in AIDS
patients with cryptococcal meningitis.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Treatments:
Amphotericin B BB 1101 Dexamethasone Dexamethasone 21-phosphate Dexamethasone acetate Fluconazole Flucytosine Liposomal amphotericin B