Dexamethasone for the Treatment of Established Postoperative Nausea and Vomiting
Status:
Terminated
Trial end date:
2017-11-09
Target enrollment:
Participant gender:
Summary
Postoperative nausea and vomiting (PONV) are frequent after surgery and anaesthesia.
Dexamethasone is widely used as antiemetic for the prevention of PONV. Little is known about
the efficacy of antiemetic drugs for the treatment of established PONV symptoms. No single
randomised trial has been published so far that tests the efficacy of dexamethasone for the
treatment of established PONV symptoms. In this trial the investigators want to test the
antiemetic efficacy of three different doses of intravenous dexamethasone for the treatment
of established PONV symptoms. In adjunct protocols of this study the investigators aim to
establish a novel method to quantify the anti-nausea efficacy of an antiemetic drug, to study
pharmacogenetics of PONV, and to further our understanding on the smoking status as a
predictive factor of PONV.